RNA Details
Disease Name
scleroderma systemic
Tissue
skin
RNA Symbol
mir-150
RNA ID
RNA Type
miRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
MiR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin beta3
Year
2013
Function
"We found that mir-150 is detectable and quantitative in serum. Serum mir-150 levels were decreased in ssc patients, and the ssc patients with lower serum mir-150 levels tended to have more severe clinical manifestations. Mir-150 may play an important role in the pathogenesis of ssc via overexpression of integrin beta3. Investigation of the regulatory mechanisms of tissue fibrosis by mir-150 could lead to development of new diagnostic tools and new treatments using mirna."